CAS No. 1185763-69-2
Batch:
Purity:99.78
Chemical Structure
Check the
NVP-BVU972
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-[[6-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]quinoline | |
|---|---|---|
| CAS Number | 1185763-69-2 | |
| Molecular Formula |
C20H16N6 |
|
| Molecular Weight (MW) | 340.38 | |
| SMILES | CN1C=C(C=N1)C2=NN3C(=NC=C3CC4=CC5=C(C=C4)N=CC=C5)C=C2 | |
| InChIKey | RNCNPRCUHHDYPC-UHFFFAOYSA-N |
NVP-BVU972 is a potent and selective MET kinase inhibitor that displays high selectivity over related kinases such as RON. It potently suppresses both constitutive and HGF-stimulated MET autophosphorylation, thereby inhibiting downstream HGF/MET signaling cascades. Consequently, NVP-BVU972 impairs cellular growth and proliferation in MET-amplified cancer cell lines, making it a key tool for exploring MET-dependent oncogenesis and mutational resistance mechanisms. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
68 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 68 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.