CAS No. 1942919-79-0

Batch: Purity:99.95
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NVP-BSK805 2HCl Chemical Structure
Chemical Structure
Check the NVP-BSK805 2HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[[2,6-difluoro-4-[3-(1-piperidin-4-ylpyrazol-4-yl)quinoxalin-5-yl]phenyl]methyl]morpholine;dihydrochloride
CAS Number 1942919-79-0
Molecular Formula

C27H28F2N6O.2HCl
Molecular Weight (MW) 563.47
SMILES C1CNCCC1N2C=C(C=N2)C3=NC4=C(C=CC=C4N=C3)C5=CC(=C(C(=C5)F)CN6CCOCC6)F.Cl.Cl
InChIKey NUOCAPALWRHKCU-UHFFFAOYSA-N

Ordering Information

Biological Activity

NVP-BSK805 dihydrochloride is a potent, ATP-competitive JAK2 inhibitor targeting JAK2 JH1 (IC50 =, wild-type JAK2 (IC50 =, and JAK2 V617F (IC50 =, with over 20-fold selectivity over JAK1 and JAK3. Inhibition of JAK2 suppresses downstream STAT5 phosphorylation, thereby blocking cell proliferation and inducing apoptosis in JAK2 V617F-bearing leukemic cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (177.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 6 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.