CAS No. 2245892-85-5

Batch: Purity:99.56
Check CoA
NVP-BHG712 isomer Chemical Structure
Chemical Structure
Check the NVP-BHG712 isomer product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 2245892-85-5
Molecular Formula

C26H20F3N7O
Molecular Weight (MW) 503.48
SMILES C[N]1C=C2C(=NC(=NC2=N1)C3=CC=CN=C3)NC4=CC(=CC=C4C)C(=O)NC5=CC=CC(=C5)C(F)(F)F

Biological Activity

NVP-BHG712 isomer is a receptor tyrosine kinase inhibitor targeting erythropoietin-producing hepatocellular (EPH) family receptors, including EPHA2 and EPHB4. By binding to these kinase domains, it modulates intercellular signaling to regulate cell morphology, adhesion, and cell migration. The regioisomer exhibits distinct kinase binding modes, affinity profiles, and selectivity compared to its parent compound. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (198.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 2 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Tröster A, et al. ChemMedChem. 2018;13(16):1629-1633.

Jump to

Note: Technical data last updated: Sep 1, 2026.