CAS No. 475-83-2

Batch: Purity:99.92
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Nuciferine Chemical Structure
Chemical Structure
Check the Nuciferine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 475-83-2
Molecular Formula

C19H21NO2
Molecular Weight (MW) 295.38
SMILES CN1CCC2=CC(=C(C3=C2C1CC4=CC=CC=C43)OC)OC

Ordering Information

Biological Activity

Nuciferine is an active aporphine alkaloid that acts as a multitarget ligand across serotonin and dopamine receptor families. It functions as an antagonist at 5-HT2A, 5-HT2C, and 5-HT2B receptors, an inverse agonist at 5-HT7 receptors, a partial agonist at D2, D5, and 5-HT6 receptors, and an agonist at 5-HT1A and D4 receptors. Modulation of these G-protein coupled receptor pathways regulates cAMP signaling and downstream neuronal responses, exhibiting antipsychotic and metabolic actions. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 7 mg/mL (23.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.