CAS No. 1415800-43-9
| CAS Number | 1415800-43-9 | |
|---|---|---|
| Molecular Formula |
C32H43N5O2 |
|
| Molecular Weight (MW) | 529.72 | |
| SMILES | C1CCN(C1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)C(=O)N4CCC(CC4)N5CCCC5)NC6=CC=CC=C6 |
UNC1215 is a potent and selective malignant brain tumor (MBT) domain antagonist that targets L3MBTL3, Kd 120 nM) with greater than 50-fold selectivity over other human MBT domain family members. By competing with methylated lysine residues for binding to L3MBTL3, UNC1215 disrupts chromocenter localization and modulates chromatin dynamics, providing a valuable chemical probe for investigating MBT domain-mediated epigenetic regulation and cellular phenotypes. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(188.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| Ethanol | 55 mg/mL |
| DMSO |
20 mg/mL
(37.75 mM)
; Warmed with 60°C water bath
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.