CAS No. 154447-35-5

Batch: Purity:99.94
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NU7026 Chemical Structure
Chemical Structure
Check the NU7026 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-morpholin-4-ylbenzo[h]chromen-4-one
CAS Number 154447-35-5
Molecular Formula

C17H15NO3
Molecular Weight (MW) 281.31
SMILES C1COCCN1C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3
InChIKey KKTZALUTXUZPSN-UHFFFAOYSA-N

Ordering Information

Biological Activity

NU7026 is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 of, exhibiting 60-fold selectivity for DNA-PK over PI3K and inactivity against ATM and ATR. By targeting DNA-PK within cellular DNA damage response pathways, NU7026 impairs double-strand break repair, leading to enhanced G2/M cell cycle arrest and increased cellular apoptosis. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
4-Methylpyridine 5 mg/mL
DMSO 1 mg/mL (3.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.