CAS No. 81624-55-7

Batch: Purity:99.64
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NSC348884 Chemical Structure
Chemical Structure
Check the NSC348884 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N,N,N',N'-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]ethane-1,2-diamine
CAS Number 81624-55-7
Molecular Formula

C38H40N10
Molecular Weight (MW) 636.79
SMILES CC1=CC2=C(C=C1)N=C(N2)CN(CCN(CC3=NC4=C(N3)C=C(C=C4)C)CC5=NC6=C(N5)C=C(C=C6)C)CC7=NC8=C(N7)C=C(C=C8)C
InChIKey KZOLQEUQAFTQFM-UHFFFAOYSA-N

Ordering Information

Biological Activity

NSC348884 is a nucleophosmin (NPM1) inhibitor that inhibits cell proliferation and induces apoptosis in various cancer cell lines with IC50 values ranging from 1.4 to. By disrupting nucleophosmin oligomerization, NSC348884 interferes with NPM1 chaperone functions and nucleolar protein interactions. This disruption leads to activation of p53 signaling pathways, cell cycle arrest, and initiation of apoptotic cascades in cancer cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (157.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.