CAS No. 1177865-17-6

Batch: Purity:99.96
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NSC 23766 Trihydrochloride Chemical Structure
Chemical Structure
Check the NSC 23766 Trihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-N-[2-[5-(diethylamino)pentan-2-ylamino]-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine;trihydrochloride
CAS Number 1177865-17-6
Molecular Formula

C24H35N7.3ClH
Molecular Weight (MW) 530.97
SMILES CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(C=C(N=C3C=C2)C)N)C.Cl.Cl.Cl
InChIKey CPUHORIUXPQCHW-UHFFFAOYSA-N

Biological Activity

NSC 23766 trihydrochloride is a selective inhibitor of Rac GTPase, targeting Rac activation mediated by guanine nucleotide exchange factors (GEFs) with an IC50 of ~in cell-free assays, without inhibiting Cdc42 or RhoA. By preventing GEF binding and Rac activation, NSC 23766 suppresses downstream Rac signaling pathways, leading to the inhibition of cell proliferation, migration, invasion, and cell cycle progression in various cell lines. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (188.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Gao H, et al. Proc Natl Acad Sci U S A. 2004;101(49):17204-9.

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Note: Technical data last updated: Sep 1, 2026.