CAS No. 123653-11-2
Batch:
Purity:99.80
Chemical Structure
Check the
NS-398 (NS398)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide | |
|---|---|---|
| CAS Number | 123653-11-2 | |
| Molecular Formula |
C13H18N2O5S |
|
| Molecular Weight (MW) | 314.36 | |
| SMILES | CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2CCCCC2 | |
| InChIKey | KTDZCOWXCWUPEO-UHFFFAOYSA-N |
NS-398 is a selective inhibitor of cyclooxygenase-2 (COX-2) that exhibits anti-inflammatory and antineoplastic properties. By inhibiting COX-2 enzymatic activity, NS-398 blocks prostaglandin E2 biosynthesis and downregulates downstream inflammatory and pro-survival signaling cascades. Consequently, NS-398 suppresses cell proliferation, promotes apoptosis, and inhibits cell migration and angiogenesis across multiple preclinical inflammation and cancer models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
62 mg/mL
(197.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
63 mg/mL
(200.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.