CAS No. 1476-53-5

Batch: Purity:99.91
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Novobiocin Sodium (Cathomycin, Albamycin) Chemical Structure
Chemical Structure
Check the Novobiocin Sodium (Cathomycin, Albamycin) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name sodium 7-[(2R,3R,4S,5R)-4-carbamoyloxy-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl]oxy-3-[[4-hydroxy-3-(3-methylbut-2-enyl)benzoyl]amino]-8-methyl-2-oxochromen-4-olate
CAS Number 1476-53-5
Molecular Formula

C31H35N2O11.Na
Molecular Weight (MW) 634.61
SMILES CC1=C(C=CC2=C1OC(=O)C(=C2O)NC(=O)C3=CC(=C(C=C3)[O-])CC=C(C)C)OC4C(C(C(C(O4)(C)C)OC)OC(=O)N)O.[Na+]
InChIKey WWPRGAYLRGSOSU-RNROJPEYSA-M

Biological Activity

Novobiocin Sodium is an aminocoumarin antibiotic that acts as a competitive inhibitor of bacterial DNA gyrase by targeting the GyrB subunit ATP-binding site, and also binds the C-terminal domain of heat shock protein 90 (Hsp90). By blocking ATPase activity, it inhibits bacterial DNA supercoiling and replication, while Hsp90 inhibition promotes the degradation of client proteins and suppresses cellular survival pathways. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (157.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 100 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Marcu MG, et al. J Biol Chem. 2000;275(47):37181-6.

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Note: Technical data last updated: Sep 1, 2026.