CAS No. 68-22-4
| CAS Number | 68-22-4 | |
|---|---|---|
| Molecular Formula |
C20H26O2 |
|
| Molecular Weight (MW) | 298.42 | |
| SMILES | CC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34 |
Norethindrone (Norethisterone) is a synthetic progestin that acts as a potent agonist of the progesterone receptor. By binding to the progesterone receptor, it mimics the actions of endogenous progesterone, regulating progesterone receptor-mediated transcription and downstream signaling pathways. This activation modulates gene expression involved in cell proliferation, differentiation, and reproductive tissue biology, exerting strong progestational activity in target cells. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
60 mg/mL
(201.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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