CAS No. 1063-77-0
Batch:
Purity:99.59
Chemical Structure
Check the
Nomilin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(1R,2R,4S,7S,8S,11R,12R,13S,18R)-7-(furan-3-yl)-1,8,12,17,17-pentamethyl-5,15,20-trioxo-3,6,16-trioxapentacyclo[9.9.0.02,4.02,8.012,18]icosan-13-yl] acetate | |
|---|---|---|
| CAS Number | 1063-77-0 | |
| Molecular Formula |
C28H34O9 |
|
| Molecular Weight (MW) | 514.56 | |
| SMILES | CC(=O)OC1CC(=O)OC(C2C1(C3CCC4(C(OC(=O)C5C4(C3(C(=O)C2)C)O5)C6=COC=C6)C)C)(C)C | |
| InChIKey | KPDOJFFZKAUIOE-WNGDLQANSA-N |
Nomilin is a naturally occurring citrus triterpenoid that acts as a potent agonist of the G protein-coupled bile acid receptor TGR5 (GPBAR1). Receptor activation by nomilin stimulates intracellular cAMP production, which triggers downstream metabolic signaling cascades. This pathway activation promotes glucose tolerance, regulates energy expenditure, and suppresses diet-induced obesity and hyperglycemia in preclinical models. In addition, nomilin exhibits antiproliferative effects in cancer cells.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(194.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.