CAS No. 16673-34-0

Batch: Purity:98.94
Check CoA
NLRP3 Inflammasome Inhibitor I Chemical Structure
Chemical Structure
Check the NLRP3 Inflammasome Inhibitor I product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide
CAS Number 16673-34-0
Molecular Formula

C16H17ClN2O4S
Molecular Weight (MW) 368.84
SMILES COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)N
InChIKey KVWWTCSJLGHLRM-UHFFFAOYSA-N

Ordering Information

Biological Activity

NLRP3 Inflammasome Inhibitor I is a synthetic small-molecule inhibitor targeting the NLRP3 inflammasome. Lacking the cyclohexylurea moiety responsible for insulin release in glyburide, this compound selectively blocks NLRP3 inflammasome activation without stimulating pancreatic beta-cell insulin secretion. Consequently, it suppresses downstream activation of caspase-1 and inhibits the maturation and release of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and interleukin-18 (IL-18). [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 73 mg/mL (197.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.