Niraparib (MK-4827): Selectivity & Specificity
Niraparib (MK-4827) is a potent inhibitor of PARP-2 (2.1 nM), PARP-1 (3.8 nM), TNKS1/2 (600 nM), and DCK. Niraparib (MK-4827) exhibits the greatest inhibitory potency toward PARP-2 (IC50 = 2.1 nM).
Niraparib (MK-4827) is a potent inhibitor of PARP-2 (2.1 nM), PARP-1 (3.8 nM), TNKS1/2 (600 nM), and DCK. Niraparib (MK-4827) exhibits the greatest inhibitory potency toward PARP-2 (IC50 = 2.1 nM).