CAS No. 1420-04-8
Batch:
Purity:99.43
Chemical Structure
Check the
niclosamide ethanolamine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-aminoethanol;5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide | |
|---|---|---|
| CAS Number | 1420-04-8 | |
| Molecular Formula |
C13H8Cl2N2O4.C2H7NO |
|
| Molecular Weight (MW) | 388.20 | |
| InChIKey | XYCDHXSQODHSLG-UHFFFAOYSA-N |
Niclosamide ethanolamine is an anthelmintic agent, mild mitochondrial uncoupler, and potent inhibitor of the STAT3 signaling pathway (IC50 =. It suppresses PI3K-mTORC1 signaling to block fibroblast proliferation and inhibits TGF-β1-induced epithelial-mesenchymal transition and extracellular matrix accumulation via the mTORC1-4EBP1 axis. Furthermore, it activates noncanonical autophagy to sensitize fibroblasts to apoptosis, conferring renoprotection in diabetic and nondiabetic kidney disease models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
78 mg/mL
(200.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.