CAS No. 1253952-02-1

Batch: Purity:99.40
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Netarsudil (AR-13324) 2HCl Chemical Structure
Chemical Structure
Check the Netarsudil (AR-13324) 2HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [4-[(2S)-3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl]phenyl]methyl 2,4-dimethylbenzoate;dihydrochloride
CAS Number 1253952-02-1
Molecular Formula

C28H27N3O3.2HCl
Molecular Weight (MW) 526.45
SMILES CC1=CC(=C(C=C1)C(=O)OCC2=CC=C(C=C2)C(CN)C(=O)NC3=CC4=C(C=C3)C=NC=C4)C.Cl.Cl
InChIKey LDKTYVXXYUJVJM-FBHGDYMESA-N

Ordering Information

Biological Activity

Netarsudil (AR-13324) 2HCl is a potent Rho kinase (ROCK) inhibitor. Targeted inhibition of ROCK signaling disrupts actin cytoskeleton organization, suppresses focal adhesion assembly, and reduces cellular contraction in trabecular meshwork cells. Downstream cellular responses include decreased actomyosin-driven cell stiffness, reduced extracellular matrix production, and altered cell morphology that modulates outflow tissue resistance. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (189.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.