CAS No. 1953130-87-4

Batch: Purity:99.83
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Nesolicaftor (PTI-428) Chemical Structure
Chemical Structure
Check the Nesolicaftor (PTI-428) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1953130-87-4
Molecular Formula

C18H18N4O4
Molecular Weight (MW) 354.36

Biological Activity

Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier that selectively increases CFTR protein expression. By enhancing immature CFTR protein synthesis at the ribosome, nesolicaftor promotes the amount of functional channel available for trafficking and processing. This increased expression enhances chloride ion transport across epithelial cell membranes, helping to restore fluid homeostasis in mucosal tissues. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 71 mg/mL (200.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] De BoeckK, et al. The Lancet Respiratory Medicine. 2016;4(8):662-674.

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Note: Technical data last updated: Sep 1, 2026.