CAS No. 1953130-87-4
Batch:
Purity:99.83
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Chemical Structure
Check the
Nesolicaftor (PTI-428)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1953130-87-4 | |
|---|---|---|
| Molecular Formula |
C18H18N4O4 |
|
| Molecular Weight (MW) | 354.36 |
Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier that selectively increases CFTR protein expression. By enhancing immature CFTR protein synthesis at the ribosome, nesolicaftor promotes the amount of functional channel available for trafficking and processing. This increased expression enhances chloride ion transport across epithelial cell membranes, helping to restore fluid homeostasis in mucosal tissues. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(200.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Nesolicaftor (PTI-428) Clinical Trials
- Nesolicaftor (PTI-428) Solubility in DMSO
- Nesolicaftor (PTI-428) Stock Solution
- Nesolicaftor (PTI-428) Storage
- Nesolicaftor (PTI-428) Stability
- Nesolicaftor (PTI-428) Molecular Weight
- Nesolicaftor (PTI-428) Chemical Structure (2D and 3D)
- Nesolicaftor (PTI-428) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.