CAS No. 1360614-48-7
| IUPAC Name | (E)-N-[4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide | |
|---|---|---|
| CAS Number | 1360614-48-7 | |
| Molecular Formula |
C18H15N5O6S2 |
|
| Molecular Weight (MW) | 461.47 | |
| SMILES | COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(S3)[N+](=O)[O-] | |
| InChIKey | FNPPHVLYVGMZMZ-XBXARRHUSA-N |
Necrosulfonamide is a potent inhibitor of mixed lineage kinase domain-like protein (MLKL) that specifically blocks necrosis. By directly binding to MLKL and preventing its oligomerization and plasma membrane translocation, Necrosulfonamide suppresses RIP3-dependent necroptotic cell death downstream of TNF-alpha signaling. This compound effectively inhibits necroptosis in human cell models without interfering with apoptosis pathways, serving as a critical tool for dissecting necroptotic signaling mechanisms. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(199.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
92 mg/mL
(199.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
92 mg/mL
(199.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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