2D Structure
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2D chemical structural formula diagram.
3D Structure
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This 3D model represents a theoretically simulated conformation and is for reference only.
Check the
Necrostatin-1 (Nec-1)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one | |
|---|---|---|
| CAS Number | 4311-88-0 | |
| Molecular Formula |
C13H13N3OS |
|
| Molecular Weight (MW) | 259.33 | |
| SMILES | CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32 | |
| InChIKey | TXUWMXQFNYDOEZ-UHFFFAOYSA-N |
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(219.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
52 mg/mL
(200.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Necrostatin-1 (Nec-1) Mechanism of Action: RIPK1 Inhibition in Neuronal Cell Research
- Necrostatin-1 (Nec-1) Working Concentration | Cell Culture | Treatment
- Necrostatin-1 (Nec-1) Solubility in DMSO
- Necrostatin-1 (Nec-1) Stock Solution
- Necrostatin-1 (Nec-1) Storage
- Necrostatin-1 (Nec-1) Stability
- Necrostatin-1 (Nec-1) Combination Database
- Necrostatin-1 (Nec-1) Molecular Weight
- Necrostatin-1 (Nec-1) SMILES
- Necrostatin-1 (Nec-1) CAS Number
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- Necrostatin-1 (Nec-1) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.