CAS No. 1434635-54-7

Batch: Purity:99.97
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Firsocostat (ND-630, GS-0976) Chemical Structure
Chemical Structure
Check the Firsocostat (ND-630, GS-0976) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[1-[(2R)-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxothieno[2,3-d]pyrimidin-3-yl]-2-methylpropanoic acid
CAS Number 1434635-54-7
Molecular Formula

C28H31N3O8S
Molecular Weight (MW) 569.63
SMILES CC1=C(SC2=C1C(=O)N(C(=O)N2CC(C3=CC=CC=C3OC)OC4CCOCC4)C(C)(C)C(=O)O)C5=NC=CO5
InChIKey ZZWWXIBKLBMSCS-FQEVSTJZSA-N

Ordering Information

Biological Activity

Firsocostat (ND-630, GS-0976) is an orally bioavailable, reversible acetyl-CoA carboxylase inhibitor targeting human ACC1 and human ACC2. By binding the biotin carboxylase domain of ACC, firsocostat blocks the conversion of acetyl-CoA to malonyl-CoA, effectively inhibiting de novo lipogenesis. Consequently, this target inhibition reduces hepatic steatosis, decreases fatty acid synthesis, and improves insulin sensitivity in liver tissue models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (175.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 4 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.