CAS No. 1802088-50-1
Batch:
Purity:99.99
Chemical Structure
Check the
NCT-501
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 8-[[4-(cyclopropanecarbonyl)piperazin-1-yl]methyl]-1,3-dimethyl-7-(3-methylbutyl)purine-2,6-dione | |
|---|---|---|
| CAS Number | 1802088-50-1 | |
| Molecular Formula |
C21H32N6O3 |
|
| Molecular Weight (MW) | 416.52 | |
| SMILES | CC(C)CCN1C(=NC2=C1C(=O)N(C(=O)N2C)C)CN3CCN(CC3)C(=O)C4CC4 | |
| InChIKey | FSXIBBYWVGWQJL-UHFFFAOYSA-N |
NCT-501 is a potent and selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1) with an IC50 of. By blocking ALDH1A1 enzymatic function, NCT-501 effectively reduces intracellular ALDH activity, downregulates stemness-associated signaling pathways, and inhibits cancer stem cell-like phenotypes, including self-renewal, colony formation, and spheroid growth across multiple cancer cell lines. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
32 mg/mL
(76.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.