CAS No. 1037592-40-7
Batch:
Purity:99.73
Chemical Structure
Check the
JPH203 (Nanvuranlat)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-2-amino-3-[4-[(5-amino-2-phenyl-1,3-benzoxazol-7-yl)methoxy]-3,5-dichlorophenyl]propanoic acid | |
|---|---|---|
| CAS Number | 1037592-40-7 | |
| Molecular Formula |
C23H19Cl2N3O4 |
|
| Molecular Weight (MW) | 472.32 | |
| SMILES | C1=CC=C(C=C1)C2=NC3=CC(=CC(=C3O2)COC4=C(C=C(C=C4Cl)CC(C(=O)O)N)Cl)N | |
| InChIKey | XNRZJPQTMQZBCE-SFHVURJKSA-N |
JPH203 (Nanvuranlat) is a selective L-type amino acid transporter 1 (LAT1) inhibitor that suppresses leucine uptake with an IC50 of 0.06 µM. By blocking LAT1-mediated amino acid transport, JPH203 inhibits HT-29 cell proliferation with an IC50 of 4.1 µM. Disruption of intracellular leucine supply leads to the downregulation of mTORC1 signaling, ultimately inducing growth arrest and apoptosis in colon and oral cancer cells. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| 5%TFA | 2.31 mg/mL |
| DMSO |
0.01 mg/mL
(0.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| DMSO |
50 mg/mL
(105.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
94 mg/mL
(199.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
50 mg/mL
(105.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
3 mg/mL
(6.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- JPH203 (Nanvuranlat) Mechanism of Action: LAT1 Inhibition in Biliary Tract Cancer Cell Research
- JPH203 (Nanvuranlat) Clinical Trials
- JPH203 (Nanvuranlat) Working Concentration | Cell Culture | Treatment
- JPH203 (Nanvuranlat) Solubility in DMSO
- JPH203 (Nanvuranlat) Stock Solution
- JPH203 (Nanvuranlat) Storage
- JPH203 (Nanvuranlat) Stability
- JPH203 (Nanvuranlat) Combination Database
- JPH203 (Nanvuranlat) Molecular Weight
- JPH203 (Nanvuranlat) SMILES
- JPH203 (Nanvuranlat) Chemical Structure (2D and 3D)
- JPH203 (Nanvuranlat) IC50 for Cell-based and Cell-free Assays
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- JPH203 (Nanvuranlat) Sigma (ADVH9B9B326E)? Try a better option.
- JPH203 (Nanvuranlat) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.