CAS No. 42200-33-9
Batch:
Purity:99.26
Chemical Structure
Check the
Nadolol
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol | |
|---|---|---|
| CAS Number | 42200-33-9 | |
| Molecular Formula |
C17H27NO4 |
|
| Molecular Weight (MW) | 309.40 | |
| SMILES | CC(C)(C)NCC(COC1=CC=CC2=C1CC(C(C2)O)O)O | |
| InChIKey | VWPOSFSPZNDTMJ-UCWKZMIHSA-N |
Nadolol is a non-selective beta-adrenergic receptor antagonist that targets both beta-1 and beta-2 adrenoceptors. By inhibiting agonist binding to these G-protein coupled receptors, Nadolol suppresses adenylyl cyclase activation and downstream cyclic AMP (cAMP) accumulation. This attenuation of G-protein signaling downregulates protein kinase A (PKA) pathway activity, blunting beta-adrenergic-mediated intracellular signaling and modulating cellular electrophysiological and contractile functions. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
61 mg/mL
(197.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
62 mg/mL
(200.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.