CAS No. 131-48-6

Batch: Purity:99.82
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N-Acetylneuraminic acid Chemical Structure
Chemical Structure
Check the N-Acetylneuraminic acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S,4S,5R,6R)-5-acetamido-2,4-dihydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
CAS Number 131-48-6
Molecular Formula

C11H19NO9
Molecular Weight (MW) 309.27
SMILES CC(=O)NC1C(CC(OC1C(C(CO)O)O)(C(=O)O)O)O
InChIKey SQVRNKJHWKZAKO-PFQGKNLYSA-N

Biological Activity

N-Acetylneuraminic acid is a predominant endogenous sialic acid and monosaccharide building block that terminates glycan chains on membrane glycoproteins and glycolipids. It modulates intercellular recognition, cell-cell adhesion, and signaling events by serving as a ligand for lectins such as Siglecs and selectins. Furthermore, terminal N-acetylneuraminic acid residues impart negative surface charge to biological membranes, regulating molecular interactions, endocytosis, and cell surface receptor stability.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 62 mg/mL (200.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 62 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.