CAS No. 2416417-65-5

Batch: Purity:99.37
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MYF-01-37 Chemical Structure
Chemical Structure
Check the MYF-01-37 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[3-methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one
CAS Number 2416417-65-5
Molecular Formula

C15H17F3N2O
Molecular Weight (MW) 298.3
SMILES CC1(CCN(C1)C(=O)C=C)NC2=CC=CC(=C2)C(F)(F)F
InChIKey MTBDEVWWJBIUOK-UHFFFAOYSA-N

Biological Activity

MYF-01-37 is a novel covalent inhibitor of transcriptional enhancer associate domain (TEAD) transcription factors, specifically targeting the conserved Cys380 residue. By alkylating Cys380 within the TEAD palmitoylation pocket, it disrupts TEAD autopalmitoylation and impairs interaction with YAP/TAZ co-activators. Inhibition of the Hippo pathway downstream transcriptional network suppresses TEAD-mediated gene expression, leading to attenuated cell proliferation and altered tumor signaling phenotypes.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 60 mg/mL (201.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 60 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.