CAS No. 53678-77-6

Batch: Purity:97
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Muramyl dipeptide (MDP) Chemical Structure
Chemical Structure
Check the Muramyl dipeptide (MDP) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (4R)-4-[[(2S)-2-[[(2R)-2-[(2R,3R,4R,5R)-2-acetamido-4,5,6-trihydroxy-1-oxohexan-3-yl]oxypropanoyl]amino]propanoyl]amino]-5-amino-5-oxopentanoic acid
CAS Number 53678-77-6
Molecular Formula

C19H32N4O11
Molecular Weight (MW) 492.48
SMILES CC(NC(=O)C(C)OC1C(O)C(CO)OC(O)C1NC(C)=O)C(=O)NC(CCC(O)=O)C(N)=O
InChIKey MEJOVVKHFORGKW-HOMBLFBHSA-N

Ordering Information

Biological Activity

Muramyl dipeptide (MDP) is a peptidoglycan motif that acts as a potent agonist of the intracellular receptor NOD2. Recognition of MDP by NOD2 triggers NF-kB signaling pathways, leading to downstream activation of immune and inflammatory responses. Through NOD2-mediated signaling, MDP regulates gene expression and host recognition of bacterial components in target cells. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 98 mg/mL (198.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 98 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.