CAS No. 12650-69-0

Batch: Purity:99.64
Check CoA
Mupirocin Chemical Structure
Chemical Structure
Check the Mupirocin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid
CAS Number 12650-69-0
Molecular Formula

C26H44O9
Molecular Weight (MW) 500.62
SMILES CC(C1C(O1)CC2COC(C(C2O)O)CC(=CC(=O)OCCCCCCCCC(=O)O)C)C(C)O
InChIKey MINDHVHHQZYEEK-HBBNESRFSA-N

Ordering Information

Biological Activity

Mupirocin is a natural antibiotic that acts as a potent inhibitor of bacterial isoleucyl-tRNA synthetase. By selectively binding to the isoleucyl-tRNA synthetase enzyme, it competitively inhibits the formation of isoleucyl-tRNA from isoleucine and ATP. This inhibition blocks bacterial protein synthesis, leading to the suppression of bacterial growth and effective antibacterial activity against susceptible Gram-positive pathogens. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (199.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.