MRTX1133 is a potent, selective, noncovalent KRAS G12D inhibitor. It affects KRAS/MAPK and PI3K/AKT signaling pathways by binding to the KRAS G12D protein, effectively inhibiting tumor cell proliferation, migration, and growth.
MRTX1133: Mechanism of Action
MRTX1133 MOA：Targeting KRAS G12D/MAPK Pathway for Pancreatic Ductal Adenocarcinoma