CAS No. 453562-69-1

Batch: Purity:99.99
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Motesanib (AMG-706) Chemical Structure
Chemical Structure
Check the Motesanib (AMG-706) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide
CAS Number 453562-69-1
Molecular Formula

C22H23N5O
Molecular Weight (MW) 373.45
SMILES CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C
InChIKey RAHBGWKEPAQNFF-UHFFFAOYSA-N

Ordering Information

Biological Activity

Motesanib (AMG-706) is an orally bioavailable receptor tyrosine kinase inhibitor targeting VEGFR1 (IC50 2 nM), VEGFR2 (IC50 3 nM), VEGFR3, Kit, Ret, and PDGFR. By blocking VEGFR and receptor tyrosine kinase signaling pathways, it suppresses endothelial cell proliferation, capillary tube formation, and vascular permeability. Consequently, Motesanib inhibits tumor angiogenesis and suppresses tumor growth in xenograft models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 18.2 mg/mL (48.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 8 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.