CAS No. 151767-02-1

Batch: Purity:99.86
Check CoA
Montelukast Sodium Chemical Structure
Chemical Structure
Check the Montelukast Sodium product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 151767-02-1
Molecular Formula

C35H36ClNO3S.Na
Molecular Weight (MW) 608.17
SMILES CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)SCC5(CC5)CC(=O)[O-])O.[Na+]

Biological Activity

Montelukast Sodium is a potent and selective cysteinyl leukotriene receptor 1 (CysLT1) antagonist that blocks leukotriene D4 (LTD4)-mediated signaling. By binding to CysLT1, it prevents LTD4-induced activation of downstream inflammatory pathways, thereby reducing airway smooth muscle contraction, vascular permeability, and inflammatory cell recruitment. Furthermore, Montelukast enhances macroautophagy to promote cellular homeostasis in preclinical models.

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (164.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 100 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.

Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.

Jump to

Note: Technical data last updated: Sep 1, 2026.