CAS No. 1154028-82-6
Batch:
Purity:99.82
-chemical-structure-s8138.gif)
Chemical Structure
Check the
Molidustat (BAY 85-3934)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(triazol-1-yl)-1H-pyrazol-3-one | |
|---|---|---|
| CAS Number | 1154028-82-6 | |
| Molecular Formula |
C13H14N8O2 |
|
| Molecular Weight (MW) | 314.30 | |
| SMILES | C1COCCN1C2=NC=NC(=C2)N3C(=O)C(=CN3)N4C=CN=N4 | |
| InChIKey | IJMBOKOTALXLKS-UHFFFAOYSA-N |
Molidustat (BAY 85-3934) is a potent hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor targeting PHD1, PHD2, and PHD3. Inhibition of HIF-PH enzymes prevents the degradation of hypoxia-inducible factor alpha subunits (HIF-1α and HIF-2α), leading to their accumulation and nuclear translocation. This stabilization activates downstream transcription of target genes, notably increasing erythropoietin production to stimulate erythropoiesis. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10 mg/mL
(31.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
2 mg/mL
(6.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| 5%TFA | 1.67 mg/mL |
| Water | Insoluble |
| DMSO |
6 mg/mL
(19.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Molidustat (BAY 85-3934) Clinical Trials
- Molidustat (BAY 85-3934) Solubility in DMSO
- Molidustat (BAY 85-3934) Stock Solution
- Molidustat (BAY 85-3934) Storage
- Molidustat (BAY 85-3934) Stability
- Molidustat (BAY 85-3934) Molecular Weight
- Molidustat (BAY 85-3934) SMILES
- Molidustat (BAY 85-3934) Chemical Structure (2D and 3D)
- Molidustat (BAY 85-3934) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.