For research use only. Not for use in humans.

Mogamulizumab (Anti-CCR4 / CD194)

Synonyms: KW-0761 Cat.No.A2568 Purity:99%

Mogamulizumab (Anti-CCR4 / CD194) is a defucosylated humanized recombinant monoclonal antibody targeting CCR4. Mogamulizumab can eliminate tumor cells by antibody-dependent cellular cytotoxicity (ADCC). Mogamulizumab can be used in the research of cancers, adult T-cell leukemia/lymphoma (ATLL), cutaneous T-cell lymphoma (CTCL). MW:145.5 KD.

Quality Control

Batch: A256801 Purity: 99% Protein concentration: 6.86mg/ml Endotoxin Level: ＜1EU/mg

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COA
SDS
Datasheet

Featured Inhibitors	Y-27632 Dihydrochloride SB431542 CHIR-99021 (Laduviglusib) RMC-7977 RMC-6236 (Daraxonrasib) MRTX1133 MG132 Z-VAD-FMK VT3989 IAG933

Specificity

Name	Citation	CCR	CCR1	CCR2	CCR3	CCR4	CCR5	CCR9	CCL	Others
SB-328437	0				++
INCB3344	5			++						mCCR2
RS504393	1			+
C-021	0					+
Vercirnon	0							+++
BX471 (ZK-811752)	2		++++
PF-4136309	1			++
Vicriviroc maleate	1	+++					+++
RS-102895 Hydrochloride	0			+						human α1a receptor,human α1d receptor,5-HT1a receptor
RS102895	2			+
TAK-779	0	++++					++++			CXCR3
AZD2098	1					++
Adaptavir (DAPTA)	3	++++					++++
R243	1	✔
Perillaldehyde	1								✔	NRF2/HO1,ROS,AhR
Cenicriviroc	8			✔						HIV-2,HIV-1
Isuzinaxib (APX-115 free base)	0								✔	TNFα,IL-6,NOX2
SB-297006	2				✔
BMS-813160	2			✔
Bindarit (AF 2838)	23								✔

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Mogamulizumab (Anti-CCR4 / CD194) is a defucosylated humanized recombinant monoclonal antibody targeting CCR4. Mogamulizumab can eliminate tumor cells by antibody-dependent cellular cytotoxicity (ADCC). Mogamulizumab can be used in the research of cancers, adult T-cell leukemia/lymphoma (ATLL), cutaneous T-cell lymphoma (CTCL). MW:145.5 KD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1159266-37-1
Molecular Weight	144.12 kDa
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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