ML385 is a specific and selective Nrf2 inhibitor. It affects Nrf2/HO-1 and Keap1/Nrf2/ARE signaling pathways by blocking Nrf2 nuclear translocation and transcriptional activity, effectively promoting oxidative stress, ferroptosis, and apoptosis.
ML385 IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for ML385 Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.