CAS No. 846557-71-9
Batch:
Purity:99.92
Chemical Structure
Check the
ML385
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide | |
|---|---|---|
| CAS Number | 846557-71-9 | |
| Molecular Formula |
C29H25N3O4S |
|
| Molecular Weight (MW) | 511.59 | |
| SMILES | CC1=CC=CC=C1C(=O)N2CCC3=C2C=CC(=C3)C4=C(SC(=N4)NC(=O)CC5=CC6=C(C=C5)OCO6)C | |
| InChIKey | LINHYWKZVCNAMQ-UHFFFAOYSA-N |
ML385 is a novel and specific NRF2 inhibitor with an IC50 of. By directly binding to the Neh1 domain of NRF2, ML385 disrupts the NRF2-MAFG complex and blocks its transcriptional activity. This leads to reduced downstream expression of target genes involved in antioxidant responses, effectively modulating lipid peroxidation and sensitizing hyperactive cancer cells to ferroptosis. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
20 mg/mL
(39.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
50 mg/mL
(97.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
50 mg/mL
(97.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(195.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- ML385 Mechanism of Action: NRF2 Inhibition in Cancer Cell Research
- ML385 Working Concentration | Cell Culture | Treatment
- ML385 Solubility in DMSO
- ML385 Stock Solution
- ML385 Storage
- ML385 Stability
- ML385 Combination Database
- ML385 Molecular Weight
- ML385 SMILES
- ML385 Chemical Structure (2D and 3D)
- ML385 IC50 for Cell-based and Cell-free Assays
- ML385 Sigma (SML1833)? Try a better option.
- ML385 MedChemExpress (HY-100523)? Try a better option.
- ML385 Cayman (21114)? Try a better option.
- ML385 Axonmedchem (Axon 2671)? Try a better option.
- ML385 Tocris (6243)? Try a better option.
- ML385 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.