CAS No. 1069858-99-6
Batch:
Purity:99.18
Chemical Structure
Check the
ML359
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | ethyl 1-[(3-chloro-4-hydroxyphenyl)methyl]-4-(2-phenoxyethyl)piperidine-4-carboxylate | |
|---|---|---|
| CAS Number | 1069858-99-6 | |
| Molecular Formula |
C23H28ClNO4 |
|
| Molecular Weight (MW) | 417.93 | |
| SMILES | CCOC(=O)C1(CCOC2=CC=CC=C2)CCN(CC1)CC3=CC=C(O)C(=C3)Cl | |
| InChIKey | DCLHRRNJOZJGKD-UHFFFAOYSA-N |
ML359 is a small-molecule inhibitor targeting protein disulfide isomerase (PDI). By suppressing PDI activity within the endoplasmic reticulum, ML359 disrupts proper oxidative protein folding and disulfide bond formation. This inhibition triggers endoplasmic reticulum stress, activates the unfolded protein response pathway, and subsequently leads to apoptosis and inhibition of cellular proliferation in target cells. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(200.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 84 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.