CAS No. 1360705-96-9
Batch:
Purity:99.97
Chemical Structure
Check the
ML-210
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone | |
|---|---|---|
| CAS Number | 1360705-96-9 | |
| Molecular Formula |
C22H20Cl2N4O4 |
|
| Molecular Weight (MW) | 475.32 | |
| SMILES | CC1=C(C(=NO1)C(=O)N2CCN(CC2)C(C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl)[N+](=O)[O-] | |
| InChIKey | VIBHJPDPEVVDTB-UHFFFAOYSA-N |
ML-210 is a selective covalent inhibitor of cellular glutathione peroxidase 4 (GPX4) with an EC50 of. By inhibiting GPX4, ML-210 impairs cellular antioxidant defense mechanisms, resulting in toxic lipid peroxide accumulation and the induction of ferroptosis. Furthermore, ML-210 selectively induces cell death in cells expressing mutant RAS, exhibiting potent anti-cancer activity. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
24 mg/mL
(50.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
| DMSO |
15 mg/mL
(31.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.