CAS No. 71203-35-5

Batch: Purity:99.77
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ML141 (CID-2950007) Chemical Structure
Chemical Structure
Check the ML141 (CID-2950007) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide
CAS Number 71203-35-5
Molecular Formula

C22H21N3O3S
Molecular Weight (MW) 407.49
SMILES COC1=CC=C(C=C1)C2CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C4=CC=CC=C4
InChIKey QBNZBMVRFYREHK-UHFFFAOYSA-N

Biological Activity

ML141 is a potent, selective, and reversible non-competitive inhibitor of Cdc42 GTPase (IC50 =. It exhibits marked selectivity against other Rho family GTPase members, including Rac1, Rab2, and Rab7. Blockade of Cdc42 function disrupts downstream cellular signaling pathways, leading to increased p38 activation and subsequently driving p38-dependent apoptosis and senescence phenotypes in targeted cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 81 mg/mL (198.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Surviladze Z, et al.

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Note: Technical data last updated: Sep 1, 2026.