CAS No. 1394371-71-1

Batch: Purity:99.46
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MK-8722 Chemical Structure
Chemical Structure
Check the MK-8722 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3R,3aR,6R,6aR)-6-[[6-chloro-5-(4-phenylphenyl)-1H-imidazo[4,5-b]pyridin-2-yl]oxy]-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol
CAS Number 1394371-71-1
Molecular Formula

C24H20ClN3O4
Molecular Weight (MW) 449.89
SMILES OC1COC2C(COC12)OC3=NC4=NC(=C(Cl)C=C4[NH]3)C5=CC=C(C=C5)C6=CC=CC=C6
InChIKey XQMNBTZLYOOAGA-UGESXGAOSA-N

Ordering Information

Biological Activity

MK-8722 is a direct, allosteric activator of mammalian AMP-activated protein kinase (AMPK) heterotrimeric complexes. Pharmacological activation of the AMPK signaling pathway by MK-8722 stimulates insulin-independent cellular glucose uptake and glycogen synthesis in skeletal muscle. Consequently, downstream AMPK activation enhances systemic glucose disposal and improves glycemic control in animal models without inducing hypoglycemia. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 90 mg/mL (200.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 3 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.