CAS No. 1184173-73-6

Batch: Purity:99.92
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MK-8353 (SCH900353) Chemical Structure
Chemical Structure
Check the MK-8353 (SCH900353) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3S)-3-methylsulfanyl-1-[2-[4-[4-(1-methyl-1,2,4-triazol-3-yl)phenyl]-3,6-dihydro-2H-pyridin-1-yl]-2-oxoethyl]-N-[3-(6-propan-2-yloxy-3-pyridinyl)-1H-indazol-5-yl]pyrrolidine-3-carboxamide
CAS Number 1184173-73-6
Molecular Formula

C37H41N9O3S
Molecular Weight (MW) 691.84
SMILES CC(C)OC1=NC=C(C=C1)C2=NNC3=C2C=C(C=C3)NC(=O)C4(CCN(C4)CC(=O)N5CCC(=CC5)C6=CC=C(C=C6)C7=NN(C=N7)C)SC
InChIKey KPQQGHGDBBJGFA-QNGWXLTQSA-N

Ordering Information

Biological Activity

MK-8353 (SCH900353) is an orally bioavailable inhibitor of extracellular signal-regulated kinase 1 (ERK1) and ERK2. By directly suppressing MAPK/ERK signaling downstream of MEK, MK-8353 inhibits the phosphorylation of ERK targets, leading to cell cycle arrest, inhibition of tumor cell proliferation, and suppression of oncogenic signaling in cancer cells driven by RAS or RAF mutations. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (72.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.