CAS No. 1219737-12-8
Batch:
Purity:99.28
Chemical Structure
Check the
MK-3903
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-[[6-chloro-5-(4-phenylphenyl)-1H-benzimidazol-2-yl]oxy]-2-methylbenzoic acid | |
|---|---|---|
| CAS Number | 1219737-12-8 | |
| Molecular Formula |
C27H19ClN2O3 |
|
| Molecular Weight (MW) | 454.90 | |
| SMILES | CC1=C(C=C(C=C1)OC2=NC3=C(N2)C=C(C(=C3)C4=CC=C(C=C4)C5=CC=CC=C5)Cl)C(=O)O | |
| InChIKey | FIKQZQDYGXAUHC-UHFFFAOYSA-N |
MK-3903 is a potent and selective activator of AMP-activated protein kinase (AMPK) across multiple heterotrimeric complexes. Activation of AMPK leads to phosphorylation of downstream targets within metabolic signaling pathways that maintain cellular energy homeostasis. Consequently, AMPK activation enhances ATP-generating catabolic processes and suppresses ATP-consuming anabolic pathways, thereby modulating cellular lipid biosynthesis and glucose metabolism. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| 4-Methylpyridine | 23 mg/mL |
| DMSO |
5.6 mg/mL
(12.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.