CAS No. 1334850-99-5
| CAS Number | 1334850-99-5 | |
|---|---|---|
| Molecular Formula |
C29H35N2O2P.Cl |
|
| Molecular Weight (MW) | 510.03 | |
| SMILES | [Cl-].CC1(C)CC(CC(C)(C)N1[O])NC(=O)C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4 | |
| InChIKey | WKKFJIJNGHNQQW-UHFFFAOYSA-N |
Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic and scavenger of mitochondrial reactive oxygen species. By selectively scavenging mitochondrial superoxide, it suppresses intra-organellar oxidative stress and prevents peroxynitrite formation. Consequently, Mito-TEMPO treatment attenuates acetaminophen-induced RIP3 kinase expression, restores mitochondrial function, and protects hepatocytes against necrotic cell death in experimental models of acute liver injury.
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(196.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
| DMSO |
100 mg/mL
(196.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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