Clinical Trials

Minocycline Hydrochloride has been evaluated in numerous clinical trials spanning Early Phase 1 through Phase 4. These studies encompass diverse indications, including neuroinflammatory responses in sickle cell disease, intracerebral hemorrhage, stroke, major depressive disorder, fragile X syndrome, pulmonary nontuberculous mycobacterial disease, and papulopustular rosacea, with specific investigations assessing neurocognitive and psychiatric outcomes. Sponsored by both academic medical institutions and biopharmaceutical companies, recruitment statuses across these protocols range from recruiting and completed to terminated and unknown.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07735819 NOT_YET_RECRUITING
Low Grade Glioma; Glioblastoma
Barbara Ann Karmanos Cancer Institute
 2026-09 PHASE2
NCT06699966 NOT_YET_RECRUITING
Major Depressive Disorder
Stony Brook University
 2027-06 PHASE4
NCT07305896 NOT_YET_RECRUITING
Intracerebral Hemorrhage
The First Hospital of Jilin University
 2025-12-31
NCT07526987 RECRUITING
Ischaemic Stroke
Beijing Tiantan Hospital
 2026-06-05 PHASE3
NCT07237048 RECRUITING
Stroke; Ischemia Stroke; Hemorrhagic Strokes; Mortality; Morbidity; Cerebrovascular Accident (Stroke); Intracerebral Haemorrhage (ICH)
Joyce Chen
 2026-02-02 PHASE2; PHASE3
NCT07594301 RECRUITING
Acute Ischemic Stroke; Endovascular Thrombectomy; Minocycline; Posterior Circulation; Arterial Occlusion
Xiang Luo
 2026-05-19 PHASE2; PHASE3
NCT07594314 RECRUITING
Acute Ischemic Stroke; Vessel Occlusion; Endovascular Thrombectomy; Anterior Circulation Brain Infarction; Minocycline
Xiang Luo
 2026-05-21 PHASE2; PHASE3
NCT05826912 ENROLLING_BY_INVITATION
Traumatic Brain Injury
University of California, San Francisco
 2024-08-01 PHASE2
NCT07750938 NOT_YET_RECRUITING
HELICOBACTER PYLORI INFECTIONS
Qilu Hospital of Shandong University
 2026-08-01 PHASE4
NCT06246396 RECRUITING
Hypertension, Resistant to Conventional Therapy
University of Florida
 2025-01-08 PHASE4
NCT07338175 RECRUITING
Intracerebral Hemorrhage
Beijing Tiantan Hospital
 2026-04-02 PHASE3
NCT03414502 RECRUITING
Rheumatoid Arthritis
University of Nebraska
 2007-12-10 PHASE3
NCT07082855 NOT_YET_RECRUITING
Retinitis Pigmentosa; Inherited Retinal Dystrophy; Retina Disorder
Zhongshan Ophthalmic Center, Sun Yat-sen University
 2025-07-15 PHASE3
NCT07611630 NOT_YET_RECRUITING
Periodontitis
The First Affiliated Hospital of Xinxiang Medical College
 2026-05-01
NCT04876638 ACTIVE_NOT_RECRUITING
Aneurysm, Ruptured; Vasospasm, Intracranial; Delayed Cerebral Ischemia; Blood Brain Barrier Defect
University of Southern California
 2019-07-01 PHASE2
NCT05605366 NOT_YET_RECRUITING
Sickle Cell Disease; Cognitive Impairment; Cognitive Decline; Cognitive Change; Cognitive Dysfunction; Cognitive Deficit; Neuroinflammatory Response
University of Cincinnati
 2026-12-01 PHASE1
NCT07757919 NOT_YET_RECRUITING
HELICOBACTER PYLORI INFECTIONS
Qilu Hospital of Shandong University
 2026-09-01 PHASE4
NCT06537921 RECRUITING
Obesity; Major Depressive Disorder; Inflammation
King's College London
 2024-10-01
NCT07462702 NOT_YET_RECRUITING
Confluent and Reticulated Papillomatosis (CARP)
Medical University of South Carolina
 2026-09-15 EARLY_PHASE1
NCT07298057 RECRUITING
Periodontitis, Diabetes Mellitus Type 2
Case Western Reserve University
 2026-02-06 EARLY_PHASE1
NCT06120140 ACTIVE_NOT_RECRUITING
Carcinoma, Non-Small-Cell Lung
Janssen Research & Development, LLC
 2024-02-16 PHASE2
NCT01422148 NOT_YET_RECRUITING
Atrial Fibrillation
Baystate Medical Center
 2025-07 PHASE2
NCT06561698 UNKNOWN
Helicobacter Pylori Infection
Shanghai Jiao Tong University School of Medicine
 2024-08-21 PHASE4
NCT02719392 WITHDRAWN
Bipolar Disorder; Bipolar Depression
Massachusetts General Hospital
 2017-08-09 PHASE4
NCT05902819 COMPLETED
Post-traumatic Stress Disorder; Cocaine Use Disorder
Psychiatric University Hospital, Zurich
 2023-05-10
NCT05367362 WITHDRAWN
Acute Ischemic Stroke
State University of New York at Buffalo
 2025-12-01 PHASE2
NCT06561711 COMPLETED
Helicobacter Pylori Infection
Shanghai Jiao Tong University School of Medicine
 2024-08-21 PHASE4
NCT05474729 RECRUITING
Minocycline; Uveitis; Retinal Degeneration
Sun Yat-sen University
 2021-12-01 PHASE1; PHASE2
NCT07437209 COMPLETED
Non-surgical Periodontal Therapy
Center for Advanced Rejuvenation and Esthetics
 2024-12-01 PHASE4
NCT07012785 NOT_YET_RECRUITING
H. Pylori Infection
Zhongda Hospital
 2025-06
NCT05422742 ACTIVE_NOT_RECRUITING
Periodontitis
West Virginia University
 2021-10-15
NCT07068607 RECRUITING
Gastritis, Indigestion, Helicobacter Pylori Infection, Gastric Cancer, Peptic Ulcer
Yongquan Shi
 2025-04-01 PHASE4
NCT03489629 COMPLETED
Cystic Fibrosis
University of North Carolina, Chapel Hill
 2018-04-03 PHASE2
NCT06004401 UNKNOWN
The Eradication Rate of Helicobacter Pylori
Shanghai Changzheng Hospital
 2023-08-20
NCT06523764 ACTIVE_NOT_RECRUITING
Helicobacter Pylori Infection Chronic Gastrit
Xijing Hospital of Digestive Diseases
 2024-11-11 PHASE4
NCT06776445 COMPLETED
Rosacea; Rosacea Subtype 1 (Erythematotelangiectatic)
First Affiliated Hospital of Chongqing Medical University
 2024-01-05 PHASE1
NCT05487417 COMPLETED
Ischemic Stroke, Acute
Xijing Hospital
 2022-11-01 PHASE4
NCT05861258 TERMINATED
Mycobacterium Avium Complex Pulmonary Disease
Radboud University Medical Center
 2023-05-08 PHASE2
NCT05512910 ACTIVE_NOT_RECRUITING
Ischemic Stroke, Acute; Minocycline; Endovascular Treatment; Basilar Artery Occlusion
Xijing Hospital
 2023-03-04 PHASE4
NCT06201793 COMPLETED
Inflammatory Bowel Diseases
Mostafa Bahaa
 2024-01-22 PHASE2
NCT03947827 COMPLETED
Treatment Resistant Depression
Centre for Addiction and Mental Health
 2020-02-01 PHASE3
NCT06997731 COMPLETED
Periodontitis and Diabetes; Periodontitis
Kafrelsheikh University
 2023-05-20 PHASE1
NCT05630534 UNKNOWN
Intracerebral Hemorrhage
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2023-01-01 PHASE1
NCT06603688 UNKNOWN
Helicobacter Pylori Infection; Chronic Gastritis
Xijing Hospital of Digestive Diseases
 2023-11-20 PHASE4
NCT05032781 WITHDRAWN
Stroke, Ischemic
Northwell Health
 2021-06-01 PHASE1
NCT04478500 UNKNOWN
Resistant Hypertension
Royal Perth Hospital
 2020-07-02 PHASE3
NCT05575427 UNKNOWN
Hospital Infections
Mahidol University
 2022-11-24 PHASE4
NCT06033846 COMPLETED
Autoimmune Encephalitis
Xijing Hospital
 2023-10-01 PHASE2
NCT06307288 UNKNOWN
Rosacea
Second Affiliated Hospital of Xi'an Jiaotong University
 2023-10-16 PHASE4
NCT05474950 UNKNOWN
Minocycline; Cystoid Macular Edema
Sun Yat-sen University
 2019-01-01 PHASE1; PHASE2
NCT05605366 Not yet recruiting
Sickle Cell Disease|Cognitive Impairment|Cognitive Decline|Cognitive Change|Cognitive Dysfunction|Cognitive Deficit|Neuroinflammatory Response
University of Cincinnati
 2024-06-01 Phase 1
NCT06255067 UNKNOWN
Periodontitis
Ain Shams University
 2024-02-25 PHASE2; PHASE3
NCT05836740 COMPLETED
Ischemic Stroke, Acute
Beijing Tiantan Hospital
 2023-05-19 PHASE3
NCT06107725 TERMINATED
Stroke, Acute; Ischemic Stroke; Hemorrhagic Stroke; Mortality; Morbidity
Maimonides Medical Center
 2023-11-01 PHASE2; PHASE3
NCT03106740 COMPLETED
Low Back Pain; Back Pain With Radiation; Back Pain Without Radiation; Back Pain Lower Back Chronic; Back Ache; Pain, Chronic
Marco Loggia
 2017-10-10 PHASE2
NCT06207760 UNKNOWN
Depression
IRCCS Centro San Giovanni di Dio Fatebenefratelli
 2023-08-28 PHASE2
NCT05958069 UNKNOWN
Epileptic Seizures Related to Drugs
Xijing Hospital
 2023-03-01
NCT02133885 WITHDRAWN
Hypertension
University of Florida
 2023-01-30 PHASE1; PHASE2
NCT05586815 UNKNOWN
Acinetobacter Infections
Mahidol University
 2023-01-10 PHASE4
NCT06044090 COMPLETED
Stress, Psychological; Motivation
University of North Carolina, Chapel Hill
 2022-09-12 PHASE4
NCT05680389 UNKNOWN
Cerebral Amyloid Angiopathy
Leiden University Medical Center
 2020-12-02 PHASE1; PHASE2
NCT04202263 UNKNOWN
Allergic Rhinitis; Asthma
State University of New York - Downstate Medical Center
 2019-09-26 PHASE2
NCT04210713 COMPLETED
Alcohol Drinking; Alcohol-Related Disorders; Disease; Inflammation; Alcoholism; Cognitive Dysfunction; Pathologic Processes; Drinking Behavior; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorder; Cognition Disorder; Neurocognitive Disorders; Minocycline; Anti-Bacterial Agents; Anti-Infective Agents
University of Maryland, Baltimore
 2020-02-03 PHASE1
NCT06027151 COMPLETED
Periodontitis; Diabetes Mellitus
Riphah International University
 2022-10-06
NCT07804979 COMPLETED
Major Depressive Disorder (MDD); Treatment-resistant Depression (TRD)
Lahore General Hospital
 2022-05-12
NCT05597462 COMPLETED
Rosacea
Journey Medical Corporation
 2022-09-30 PHASE1
NCT05861258 Recruiting
Mycobacterium Avium Complex Pulmonary Disease
Radboud University Medical Center
 2023-05-08 Phase 2
NCT04068207 COMPLETED
Retinitis Pigmentosa; Inherited Retinal Dystrophy; Retina Disorder
Sun Yat-sen University
 2019-08-25 PHASE2
NCT05630534 Not yet recruiting
Intracerebral Hemorrhage
Second Affiliated Hospital School of Medicine Zhejiang University|The Fourth Affiliated Hospital of Zhejiang University School of Medicine|The Second Affiliated Hospital of Jiaxing University
 2023-01-01 Phase 1
NCT05530252 COMPLETED
Periodontitis
Beijing Stomatological Hospital, Capital Medical University
 2022-09-05 PHASE4
NCT02533232 UNKNOWN
Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorder
Pakistan Institute of Living and Learning
 2022-08-30 PHASE1
NCT04531059 COMPLETED
Helicobacter Pylori Infection
Shanghai Jiao Tong University School of Medicine
 2020-10-15 PHASE4
NCT04291456 TERMINATED
Multiple Sclerosis; Clinically Isolated Syndrome
University of Calgary
 2020-01-31 PHASE3
NCT03117530 SUSPENDED
Autism Spectrum Disorder
University of California, Los Angeles
 2017-04-11 PHASE1
NCT02564978 COMPLETED
Age-Related Macular Degeneration
National Eye Institute (NEI)
 2016-12-14 PHASE2
NCT04960930 COMPLETED
Acne Vulgaris
Cutia Therapeutics (Shanghai) Co., Ltd
 2021-09-17 PHASE3
NCT04594733 COMPLETED
Fibromyalgia
Medical University of South Carolina
 2021-12-06 PHASE1; PHASE2
NCT01283997 COMPLETED
Myeloma
M.D. Anderson Cancer Center
 2011-01-25 PHASE2
NCT02055963 TERMINATED
Head And Neck Cancer
M.D. Anderson Cancer Center
 2014-05-06 PHASE2
NCT04558502 UNKNOWN
Helicobacter Pylori Eradication
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2022-01-05 PHASE4
NCT05452785 COMPLETED
Pharmacokinetics
Journey Medical Corporation
 2022-05-07 PHASE1
NCT03762915 COMPLETED
SRP; Minocycline HCl Microspheres; Biomarkers
University of Minnesota
 2019-05-20 PHASE4
NCT05077813 UNKNOWN
Tuberculosis
Kafrelsheikh University
 2021-12 PHASE2
NCT04923113 COMPLETED
Helicobacter Pylori Infection
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2021-06-28
NCT02928692 UNKNOWN
Prostate Cancer; Carcinoma of the Rectum; Colon Cancer; Renal Carcinoma
RenJi Hospital
 2016-11 PHASE3
NCT04219735 COMPLETED
Delirium; Coma
Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
 2020-01-30 PHASE2
NCT03507556 ACTIVE_NOT_RECRUITING
Revascularization
Jordan University of Science and Technology
 2010-06-28
NCT04433143 UNKNOWN
Acne Vulgaris
Gang Wang
 2020-05-15
NCT04076098 COMPLETED
Periodontitis, Adult
Mahsa University
 2018-06-25 PHASE4
NCT02998151 COMPLETED
Fragile X Syndrome
Children's Hospital Medical Center, Cincinnati
 2016-01 EARLY_PHASE1
NCT04031755 COMPLETED
Autism Spectrum Disorder; Autism
Children's Hospital Medical Center, Cincinnati
 2019-04-19 PHASE1
NCT03888378 COMPLETED
Meibomian Gland Dysfunction; MGD-Meibomian Gland Dysfunction
Hovione Scientia Limited
 2019-04-02 PHASE2
NCT01793051 COMPLETED
Myeloma
M.D. Anderson Cancer Center
 2013-03-22 PHASE2
NCT02456948 COMPLETED
Major Depressive Disorder
Charite University, Berlin, Germany
 2015-01 PHASE2
NCT01173692 COMPLETED
Oropharynx Cancer
M.D. Anderson Cancer Center
 2010-07-22 PHASE2
NCT04125706 UNKNOWN
Periodontitis
Riyadh Elm University
 2019-11-01
NCT02203552 COMPLETED
Anxiety Disorder; Depression; Recurrent Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer
Ohio State University Comprehensive Cancer Center
 2015-06-23 PHASE2
NCT04020588 UNKNOWN
Schizophrenia
Hospital Psiquiatrico Infantil Dr. Juan N. Navarro, Mexico
 2019-02-25 PHASE4
NCT04104685 COMPLETED
Acne Vulgaris
Vyne Therapeutics Inc.
 2019-09-18 PHASE2
NCT01468831 COMPLETED
Retinal Vein Occlusion
National Eye Institute (NEI)
 2012-03-28 PHASE1; PHASE2
NCT04036890 COMPLETED
Periodontitis
National Dental Centre, Singapore
 2016-06-03 PHASE4
NCT02765100 COMPLETED
Bipolar Disorder; Depression; Obesity
Weill Medical College of Cornell University
 2014-10
NCT01636934 COMPLETED
Lung Cancer
M.D. Anderson Cancer Center
 2012-07 PHASE2
NCT03964935 UNKNOWN
Periodontal Pocket
University of Baghdad
 2018-12-01 PHASE2
NCT03320018 COMPLETED
Stroke, Ischemic
Stony Brook University
 2017-08-02 PHASE2; PHASE3
NCT02968602 COMPLETED
Schizophrenia; Tobacco Use
University of Maryland, Baltimore
 2017-03-31 PHASE4
NCT03369951 COMPLETED
Bacterial Infection
National Institute of Allergy and Infectious Diseases (NIAID)
 2018-03-28 PHASE4
NCT03667222 UNKNOWN
Papulopustular Rosacea
BioPharmX, Inc.
 2018-09-18 PHASE2
NCT02362529 COMPLETED
Major Depressive Disorder
Centre for Addiction and Mental Health
 2015-02 EARLY_PHASE1
NCT03263273 COMPLETED
Rosacea; Papulopustular Rosacea
Hovione Scientia Limited
 2017-10-30 PHASE2
NCT01906008 COMPLETED
Colorectal Cancer
M.D. Anderson Cancer Center
 2013-11 PHASE2
NCT02913118 UNKNOWN
Community Acquired Pneumonia
Qingfeng Pharmaceutical Group
 2016-07 PHASE4
NCT02569307 COMPLETED
At Risk Mental State (ARMS); Psychosis
Pakistan Institute of Living and Learning
 2015-10 PHASE2
NCT03291158 WITHDRAWN
Normal Healthy Volunteers
Rempex Pharmaceuticals (a wholly owned subsidiary of The Medicines Company)
 2018-04 PHASE1
NCT02703363 COMPLETED
Depression; Bipolar Disorder; Bipolar Depression; Mood Disorders
Pakistan Institute of Living and Learning
 2016-08 PHASE3
NCT02213575 COMPLETED
Hypertension
University of Florida
 2016-03-05 PHASE2
NCT02187211 COMPLETED
Alcohol Dependence
Yale University
 2015-07-01 PHASE1
NCT02133872 COMPLETED
Hypertension
University of Florida
 2014-10 PHASE2
NCT03768557 COMPLETED
Mood; Cognitive Change
University of Oxford
 2017-04-26
NCT02770378 COMPLETED
Glioblastoma
University of Ulm
 2016-11 PHASE1; PHASE2
NCT01693523 COMPLETED
Pancreatic Cancer
M.D. Anderson Cancer Center
 2013-01-28 PHASE2
NCT03142451 COMPLETED
Facial Papulopustular Rosacea
Vyne Therapeutics Inc.
 2017-06-02 PHASE3
NCT04608500 COMPLETED
Facial Papulopustular Rosacea
Vyne Therapeutics Inc.
 2017-06-01 PHASE3
NCT03050086 COMPLETED
Moderate to Severe Papulopustular Rosacea
BioPharmX, Inc.
 2017-03-29 PHASE1; PHASE2
NCT02808052 TERMINATED
Renal Insufficiency, Acute; Renal Insufficiency, Chronic; Healthy Subjects
Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.)
 2017-05-29 PHASE1
NCT02946788 COMPLETED
Acne Vulgaris
BioPharmX, Inc.
 2017-03-13 PHASE2
NCT03340350 COMPLETED
PTSD
Sriram Ramaswamy
 2017-05-10 PHASE4
NCT01828203 UNKNOWN
Spinal Cord Injuries
Rick Hansen Institute
 2013-06 PHASE3
NCT02201563 TERMINATED
Irradiation; Adverse Effect
University of Pittsburgh
 2015-11 PHASE1
NCT03244592 WITHDRAWN
Alcohol Use Disorder; Inflammation; Neurocognitive Dysfunction; Craving; Alcohol Drinking
University of California, Los Angeles
 2018-01-15 PHASE1; PHASE2
NCT02802631 COMPLETED
Normal Healthy Volunteers
Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.)
 2017-04-20 PHASE1
NCT01580969 COMPLETED
Recurrent Glioma
University of Utah
 2012-07-06 PHASE1; PHASE2
NCT02947763 COMPLETED
Periapical Periodontitis
Cairo University
 2016-11 PHASE1
NCT02815280 COMPLETED
Acne Vulgaris
Vyne Therapeutics Inc.
 2016-05 PHASE3
NCT02815267 COMPLETED
Acne Vulgaris
Vyne Therapeutics Inc.
 2016-05 PHASE3
NCT02680379 COMPLETED
Fragile X Syndrome
Université de Sherbrooke
 2016-03 PHASE2
NCT01802216 COMPLETED
Chronic Kidney Disease; Periodontal Disease
University of California, San Francisco
 2014-02
NCT01695291 COMPLETED
Obsessive Compulsive Disorder
New York State Psychiatric Institute
 2012-05 PHASE2
NCT02359006 COMPLETED
Opioid Dependence; Pain
Yale University
 2015-03-12
NCT02815332 COMPLETED
Acne Vulgaris
BioPharmX, Inc.
 2016-08 PHASE2
NCT02272270 COMPLETED
Newly Diagnosed High Grade Glioma
University of Utah
 2014-10-27 PHASE1
NCT02907437 UNKNOWN
Schizophrenia
Beer Yaakov - Ness Ziona Mental Health Center
 2015-01 PHASE3
NCT02541500 UNKNOWN
Heroin Dependence; Amphetamine Dependence
Universiti Sains Malaysia
 2013-04 PHASE3
NCT01746043 COMPLETED
Esophageal Cancer
M.D. Anderson Cancer Center
 2013-02 PHASE2
NCT02113176 WITHDRAWN
Subarachnoid Aneurysm Hemorrhage
University at Buffalo
 2010-01 PHASE1; PHASE2
NCT01805895 COMPLETED
Intracerebral Hemorrhage
Augusta University
 2013-02 PHASE1; PHASE2
NCT03040128 COMPLETED
Intracerebral Hemorrhage
University of Tennessee
 2013-06-27 PHASE1; PHASE2
NCT02124811 COMPLETED
Schizophrenia; Schizoaffective Disorder
Emory University
 2015-02 PHASE4
NCT02601963 COMPLETED
Rosacea; Papulopustular Rosacea
Vyne Therapeutics Inc.
 2015-09 PHASE2
NCT02297412 COMPLETED
Acute Pain; Breast Carcinoma; Peripheral Neuropathy
Academic and Community Cancer Research United
 2014-11 PHASE2
NCT02178813 TERMINATED
Stroke
University of Pittsburgh
 2014-07 PHASE1
NCT02263872 COMPLETED
Depressive Disorder; Mood Disorders; Depressive Disorder, Treatment Resistant; Antidepressive Agents
Pakistan Institute of Living and Learning
 2014-10 PHASE4
NCT02709096 COMPLETED
Acne Vulgaris
BioPharmX, Inc.
 2016-04 PHASE2
NCT02928965 COMPLETED
Schizophrenia and Disorders With Psychotic Features
University of Manchester
 2013-02 PHASE2
NCT01809158 COMPLETED
Schizophrenia
Addis Ababa University
 2013-04 PHASE4
NCT02695446 COMPLETED
Acne
BioPharmX, Inc.
 2016-03 PHASE4
NCT02515955 COMPLETED
Healthy
Janssen-Cilag International NV
 2015-08 PHASE1
NCT02712775 WITHDRAWN
Liver Disease
Medical University of South Carolina
 2016-03 PHASE4
NCT01779089 UNKNOWN
Diabetic Nephropathy
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
 2009-02
NCT01317550 COMPLETED
Lung Cancer
M.D. Anderson Cancer Center
 2011-07
NCT02618317 COMPLETED
Chronic Kidney Disease
University of Sao Paulo
 2013-07 PHASE4
NCT01647282 COMPLETED
Moderate to Advanced Chronic Periodontitis
University of Nebraska
 2012-10-01 PHASE4
NCT02193269 COMPLETED
Memory Impairment
Yale University
 2013-07-08 PHASE1
NCT02140164 COMPLETED
Retinitis Pigmentosa
National Eye Institute (NEI)
 2014-05 PHASE1; PHASE2
NCT01058395 COMPLETED
Traumatic Brain Injury
Wayne State University
 2010-02 PHASE1; PHASE2
NCT01429272 COMPLETED
Bipolar Disorder Depression
Laureate Institute for Brain Research, Inc.
 2011-09 PHASE3
NCT01813240 UNKNOWN
Spinal Tumors, Trauma Patients, Minocycline.
Hadassah Medical Organization
 2013-05 PHASE2; PHASE3
NCT01659320 COMPLETED
Depression
Weill Medical College of Cornell University
 2012-03
NCT01468844 COMPLETED
Retinal Vein Occlusion
National Eye Institute (NEI)
 2011-12-21 PHASE1; PHASE2
NCT02060149 UNKNOWN
Pneumonia
Xijing Hospital
 2014-03 PHASE1; PHASE2
NCT01349192 TERMINATED
Cystic Fibrosis; Methicillin-resistant Staphylococcus Aureus
University of North Carolina, Chapel Hill
 2011-04 PHASE2
NCT01561742 UNKNOWN
Schizophrenia
The University of Texas Health Science Center, Houston
 2012-02
NCT01531582 COMPLETED
Angelman Syndrome
University of South Florida
 2012-04
NCT02250859 COMPLETED
Acne
Vyne Therapeutics Inc.
 2014-09 PHASE1
NCT00666887 COMPLETED
Clinically Isolated Syndromes; Early Single Relapse of Multiple Sclerosis
Dr. Luanne Metz
 2009-01 PHASE3
NCT01517334 COMPLETED
Peri-Implantitis
OraPharma
 2012-05 PHASE3
NCT02355977 COMPLETED
Chronic Periodontitis
Zhejiang University
 2013-06 PHASE4
NCT02056665 COMPLETED
Angelman Syndrome
Puerta de Hierro University Hospital
 2014-01 PHASE2
NCT01869907 COMPLETED
Neuropathic Pain Caused by Lumbar Radicular Pain
Ziekenhuis Oost-Limburg
 2011-09 PHASE4
NCT01809340 TERMINATED
Depressive Disorder
Janssen Research & Development, LLC
 2013-06 PHASE2
NCT01574742 UNKNOWN
Unipolar Depression
Shalvata Mental Health Center
 2012-06 PHASE1
NCT01539564 COMPLETED
Peri-Implantitis
OraPharma
 2012-04 PHASE3
NCT02051296 COMPLETED
Chronic Pain; Post-operative Pain
VA Palo Alto Health Care System
 2012-01 PHASE2
NCT01134991 TERMINATED
Rosacea
Vyne Therapeutics Inc.
 2010-06 PHASE2
NCT01403662 COMPLETED
Bipolar Disorder; Bipolar Depression; Bipolar I Depression; Bipolar II Depression
University Health Network, Toronto
 2011-07 PHASE3
NCT01433055 COMPLETED
Schizophrenia
University of Maryland, Baltimore
 2011-07
NCT01219673 TERMINATED
Head And Neck Cancer
M.D. Anderson Cancer Center
 2013-03 PHASE1; PHASE2
NCT01314482 UNKNOWN
Post-operative Intercostal Neuralgia
University of Adelaide
 2010-11 PHASE2
NCT01514422 COMPLETED
Bipolar Depression
Icahn School of Medicine at Mount Sinai
 2011-05 PHASE4
NCT01362010 COMPLETED
Acne Vulgaris
Vyne Therapeutics Inc.
 2012-01 PHASE2
NCT01938508 COMPLETED
Skin Diseases
GlaxoSmithKline
 2013-05 PHASE1
NCT01133080 UNKNOWN
Schizophrenia
Shalvata Mental Health Center
 2010-06 PHASE4
NCT00473083 COMPLETED
Rash
British Columbia Cancer Agency
 2009-01 PHASE2
NCT02030912 COMPLETED
Antibiotic Resistant Bacteria
Helperby Therapeutics Ltd
 2009-12 PHASE4
NCT01029717 COMPLETED
Catheter-related Infections
Institute of Child Health
 2010-12 PHASE3
NCT01463384 COMPLETED
Mild Cognitive Impairment; Alzheimer's Disease
Huntington Medical Research Institutes
 2011-09 PHASE2
NCT00930020 TERMINATED
Acute Stroke
Singhealth Foundation
 2009-07 PHASE4
NCT01600625 COMPLETED
Meibomian Gland Dysfunction
Yonsei University
 2011-11
NCT01320982 UNKNOWN
Schizophrenia; Schizoaffective Disorder
Sheba Medical Center
 2011-03 PHASE3
NCT00418392 UNKNOWN
Pneumothorax
National Taiwan University Hospital
 2006-11 PHASE3
NCT01171326 COMPLETED
Impetigo
Vyne Therapeutics Inc.
 2010-08 PHASE2
NCT01073813 TERMINATED
Multiple Sclerosis; Optic Neuritis
University of Calgary
 2010-02 PHASE2
NCT01053156 COMPLETED
Fragile X Syndrome
University of California, Davis
 2010-01
NCT01493622 COMPLETED
Schizophrenia
Central South University
 2010-06 PHASE4
NCT05014906 COMPLETED
Rosacea
Dermatology Specialists Research
 2010-05 PHASE4
NCT01120899 COMPLETED
Diabetic Macular Edema
National Eye Institute (NEI)
 2010-04 PHASE1; PHASE2
NCT00893724 UNKNOWN
Neovascular Age-related Macular Degeneration; Diabetic Macular Edema
Mid-Atlantic Retina Consultations, Inc.
 2009-06
NCT00556491 COMPLETED
Kidney Failure, Acute; Acute Kidney Insufficiency
Tarek M. El-Achkar
 2007-12
NCT01206348 COMPLETED
Acne
Medicis Global Service Corporation
 2010-09 PHASE4
NCT01755611 COMPLETED
Skin Infections (Acne)
GlaxoSmithKline
 2011-06-17 PHASE1
NCT01134627 TERMINATED
Multiple Sclerosis, Relapsing-Remitting
Merck KGaA, Darmstadt, Germany
 2006-02 PHASE2
NCT01083420 UNKNOWN
Oral Lichen Planus
Sheba Medical Center
 2010-03 PHASE3
NCT01297816 UNKNOWN
Retinal Detachment
Shahid Beheshti University of Medical Sciences
 2010-12 PHASE2
NCT00559494 COMPLETED
Spinal Cord Injuries
University of Calgary
 2004-06 PHASE1; PHASE2
NCT00728923 COMPLETED
Obsessive Compulsive Disorder
New York State Psychiatric Institute
 2008-08 PHASE2
NCT00401921 WITHDRAWN
Carotid Stenosis
Brigham and Women's Hospital
 2006-10 PHASE2
NCT00409747 COMPLETED
Autism; Minocycline; Regressive Autism
National Institute of Mental Health (NIMH)
 2006-11 PHASE4
NCT00988026 UNKNOWN
Mild to Moderate Acne
Darier
 2009-06 PHASE4
NCT00630396 COMPLETED
Stroke, Acute
David Hess, MD
 2008-05 PHASE1; PHASE2
NCT00361257 TERMINATED
HIV Infections
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
 2007-03 PHASE2
NCT00836355 TERMINATED
Acute Ischemic Stroke
NYU Langone Health
 2009-04
NCT00855062 TERMINATED
HIV-associated Cognitive Impairment; HIV Infections
Johns Hopkins University
 2008-04 PHASE1; PHASE2
NCT00536042 COMPLETED
Asthma
State University of New York - Downstate Medical Center
 1997-10 PHASE2
NCT00662532 COMPLETED
Periodontitis
OraPharma
 2008-04 PHASE3
NCT00668746 COMPLETED
Periodontitis
OraPharma
 2007-12 PHASE4
NCT00765336 COMPLETED
Human Volunteer
Medicis Pharmaceutical Corporation
 2006-11 PHASE4
NCT00529555 COMPLETED
Adult Periodontitis
Sunstar Americas
 2006-01 PHASE3
NCT00858689 COMPLETED
Fragile X Syndrome
FRAXA Research Foundation
 2007-10
NCT00243893 COMPLETED
Aneurysms; Arteriovenous Malformations
University of California, San Francisco
 2004-07 PHASE1
NCT00277355 COMPLETED
Huntington Disease
Merit Cudkowicz
 2006-04 PHASE2; PHASE3
NCT02312609 COMPLETED
Healthy
Ranbaxy Laboratories Limited
 2008-09
NCT02312297 COMPLETED
Healthy
Ranbaxy Laboratories Limited
 2008-09
NCT00392223 TERMINATED
Acne Vulgaris
Pfizer
 2007-10 PHASE3
NCT00515255 TERMINATED
Obsessive Compulsive Disorder
Neuropharm
 2007-07 PHASE2
NCT00916461 COMPLETED
First Episode Psychosis
Stanley Medical Research Institute
 2006-05 PHASE1; PHASE2
NCT00456677 COMPLETED
Asthma
State University of New York - Downstate Medical Center
 1996-06 PHASE2
NCT00630942 COMPLETED
Primary Sclerosing Cholangitis
Mayo Clinic
 2003-02 PHASE1
NCT00733057 COMPLETED
Negative and Cognitive Symptoms in Schizophrenia
Shalvata Mental Health Center
 2003-08 PHASE3
NCT00240513 TERMINATED
Acne Vulgaris
Derm Research @ 888 Inc.
 2004-08 PHASE4
NCT00203112 COMPLETED
Relapse Remitting Multiple Sclerosis
Teva Branded Pharmaceutical Products R&D, Inc.
 2004-06 PHASE2
NCT00579644 COMPLETED
Rheumatoid Arthritis
University of Nebraska
 2001-03-28 PHASE3
NCT00063193 COMPLETED
Parkinson's Disease
University of Rochester
 2003-05 PHASE2
NCT00776542 COMPLETED
Healthy
Ranbaxy Laboratories Limited
 2002-10
NCT00777413 COMPLETED
Healthy
Ranbaxy Laboratories Limited
 2002-11
NCT00270751 UNKNOWN
Pneumothorax
National Taiwan University Hospital
 2005-04 PHASE2; PHASE3
NCT00355576 COMPLETED
Amyotrophic Lateral Sclerosis
Columbia University
 2006-07 PHASE2
NCT00047723 COMPLETED
Amyotrophic Lateral Sclerosis
National Institute of Neurological Disorders and Stroke (NINDS)
 2003-01 PHASE3
NCT00203697 UNKNOWN
Idiopathic Pulmonary Fibrosis
University of California, Los Angeles
 PHASE3
NCT00378781 WITHDRAWN
Cancer
M.D. Anderson Cancer Center
NCT00145106 COMPLETED
Acne Vulgaris
KGL, Inc.
 2002-03 PHASE4
NCT00154895 UNKNOWN
Pneumothorax
National Taiwan University Hospital
 2001-06 PHASE3
NCT00371332 COMPLETED
Periodontitis
OraPharma
 2004-01 PHASE3
NCT00839553 UNKNOWN
Pneumothorax
Far Eastern Memorial Hospital
 2007-04
NCT00294502 COMPLETED
ESRD
Henry Ford Health System
 2003-09 PHASE4
NCT01048983 WITHDRAWN
Non Small Cell Lung Cancer
M.D. Anderson Cancer Center
 PHASE1; PHASE2
NCT00146809 COMPLETED
Multi-System-Atrophy; Minocycline
German Parkinson Study Group (GPS)
 2003-12 PHASE3
NCT00029874 COMPLETED
Huntington's Disease
FDA Office of Orphan Products Development
 2001-09 PHASE1; PHASE2

(data from https://clinicaltrials.gov, updated on 2026-07-30)

Check the Minocycline Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Minocycline Hydrochloride reversibly binds to the 30S ribosomal subunit, preventing the association of aminoacyl-tRNA with the mRNA-ribosome complex and suppressing bacterial protein synthesis. Beyond its antimicrobial mechanism, this lipid-soluble compound modulates neuroinflammatory cascades and microglial activation, providing a therapeutic rationale for clinical trials evaluating its efficacy in stroke, major depressive disorder, and neurocognitive decline.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.