CAS No. 72599-27-0

Batch: Purity:97
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Miglustat (N-Butyldeoxynojirimycin) Chemical Structure
Chemical Structure
Check the Miglustat (N-Butyldeoxynojirimycin) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
CAS Number 72599-27-0
Molecular Formula

C10H21NO4
Molecular Weight (MW) 219.28
InChIKey UQRORFVVSGFNRO-UTINFBMNSA-N

Ordering Information

Biological Activity

Miglustat (N-butyldeoxynojirimycin) is an iminosugar inhibitor of ceramide glucosyltransferase that targets the initial catalytic step in glycosphingolipid biosynthesis. Inhibition of this enzyme impairs downstream cellular glycosphingolipid production and reduces lipid accumulation. In preclinical storage models, suppressing ceramide glucosyltransferase activity prevents downstream accumulation of GM2 ganglioside and significantly decreases neuronal lysosomal storage burden. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 44 mg/mL (200.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 44 mg/mL
Ethanol 22 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.