CAS No. 5370-01-4

Batch: Purity:99.96
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Mexiletine HCl Chemical Structure
Chemical Structure
Check the Mexiletine HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 5370-01-4
Molecular Formula

C11H17NO.HCl
Molecular Weight (MW) 215.72
SMILES CC1=C(C(=CC=C1)C)OCC(C)N.Cl

Biological Activity

Mexiletine HCl is a Class IB antiarrhythmic agent that acts as a potent voltage-gated sodium channel blocker. By inhibiting sodium channels, it reduces the inward sodium current (INa) during cardiac action potential depolarization. This inhibition leads to decreased automaticity and suppressed hyperexcitability in muscle and neural tissues, modulating cellular electrophysiology without significantly altering resting membrane potential.[1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 43 mg/mL (199.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 43 mg/mL
Ethanol 43 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Desaphy JF, et al. Br J Pharmacol. 2003;139(6):1099-1106.

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Note: Technical data last updated: Sep 1, 2026.