CAS No. 73573-88-3

Batch: Purity:99.97
Check CoA
Mevastatin Chemical Structure
Chemical Structure
Check the Mevastatin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
CAS Number 73573-88-3
Molecular Formula

C23H34O5
Molecular Weight (MW) 390.51
SMILES CCC(C)C(=O)OC1CCC=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O
InChIKey AJLFOPYRIVGYMJ-INTXDZFKSA-N

Ordering Information

Biological Activity

Mevastatin (ML-236B) is a competitive inhibitor of HMG-CoA reductase, displaying a binding affinity approximately 10,000 times higher than the endogenous substrate HMG-CoA. By inhibiting HMG-CoA reductase, it blocks the rate-limiting step of the mevalonate pathway, suppressing cholesterol biosynthesis and depleting downstream isoprenoid intermediates. This pathway inhibition leads to decreased cell proliferation, cell cycle arrest, and induction of apoptosis in various cellular models.

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 78 mg/mL (199.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 1 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.