CAS No. 657-24-9
Batch:
Purity:99.75
Chemical Structure
Check the
Metformin (1,1-Dimethylbiguanide)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-(diaminomethylidene)-1,1-dimethylguanidine | |
|---|---|---|
| CAS Number | 657-24-9 | |
| Molecular Formula |
C4H11N5 |
|
| Molecular Weight (MW) | 129.16 | |
| InChIKey | XZWYZXLIPXDOLR-UHFFFAOYSA-N |
Metformin is an antihyperglycemic agent that activates AMP-activated protein kinase (AMPK) in hepatocytes. Activation of hepatic AMPK by metformin suppresses acetyl-CoA carboxylase activity, downregulates gluconeogenic gene expression, and inhibits hepatic glucose production. Downstream activation of the AMPK signaling pathway promotes cellular energy homeostasis, enhances lipid oxidation, and restores metabolic balance in hepatocytes. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 130 mg/mL |
| DMSO |
26 mg/mL
(201.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 26 mg/mL |
| DMSO |
26 mg/mL
(201.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 26 mg/mL |
| Ethanol | 26 mg/mL |
| DMSO |
26 mg/mL
(201.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 26 mg/mL |
| Ethanol | 13 mg/mL |
| DMSO |
26 mg/mL
(201.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 26 mg/mL |
| Ethanol | 13 mg/mL |
| DMSO |
26 mg/mL
(201.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 26 mg/mL |
| Ethanol | 26 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Metformin (1,1-Dimethylbiguanide) Clinical Trials
- Metformin (1,1-Dimethylbiguanide) Solubility in DMSO
- Metformin (1,1-Dimethylbiguanide) Stock Solution
- Metformin (1,1-Dimethylbiguanide) Storage
- Metformin (1,1-Dimethylbiguanide) Stability
- Metformin (1,1-Dimethylbiguanide) Molecular Weight
- Metformin (1,1-Dimethylbiguanide) Chemical Structure (2D and 3D)
- Metformin (1,1-Dimethylbiguanide) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.