CAS No. 1115-70-4

Batch: Purity:99.99
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Metformin Hydrochloride Chemical Structure
Chemical Structure
Check the Metformin Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(diaminomethylidene)-1,1-dimethylguanidine;hydrochloride
CAS Number 1115-70-4
Molecular Formula

C4H11N5.HCl
Molecular Weight (MW) 165.62
SMILES CN(C)C(=N)N=C(N)N.Cl
InChIKey OETHQSJEHLVLGH-UHFFFAOYSA-N

Ordering Information

Biological Activity

Metformin Hydrochloride is a biguanide antihyperglycemic agent that suppresses hepatic gluconeogenesis and improves peripheral insulin sensitivity. It activates AMP-activated protein kinase (AMPK) in hepatocytes, leading to decreased hepatic glucose production and enhanced peripheral glucose uptake and utilization. Additionally, metformin regulates cellular energy homeostasis, attenuates hyperglycemia, and exerts anti-proliferative effects across various cancer models through MAPK pathway modulation and metabolic regulation. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 33 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.