CAS No. 5907-38-0

Batch: Purity:99.85
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Metamizole sodium hydrate Chemical Structure
Chemical Structure
Check the Metamizole sodium hydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name sodium;[(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-methylamino]methanesulfonate;hydrate
CAS Number 5907-38-0
Molecular Formula

C13H18N3NaO5S
Molecular Weight (MW) 351.35
SMILES O.[Na+].CN(C[S]([O-])(=O)=O)C1=C(C)N(C)N(C1=O)C2=CC=CC=C2
InChIKey UNZIDPIPYUMVPA-UHFFFAOYSA-M

Ordering Information

Biological Activity

Metamizole sodium hydrate is a potent cyclooxygenase (COX) inhibitor possessing antipyretic, analgesic, and spasmolytic properties. Upon administration, this compound rapidly converts into active metabolites that suppress COX enzyme activity, thereby blocking prostaglandin E2 synthesis and downstream inflammatory signaling pathways. This targeted inhibition of prostaglandin synthesis mediates its characteristic pain-relieving, fever-reducing, and muscle-relaxing systemic phenotypes. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 70 mg/mL (199.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 70 mg/mL
Ethanol 35 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.