Melamine SDS/MSDS (Safety Data Sheet)

3.1 Substances
Product name: Melamine
CAS Number: 108-78-1
PubChem CID: 7955

3.2 Mixtures
Not applicable (pure substance).

4.1 Description of first aid measures
Inhalation: Fresh air, rest.
Skin contact: Rinse and then wash skin with water and soap.
Eye contact: Rinse with plenty of water for several minutes (remove contact lenses if easily possible).
Ingestion: Rinse mouth.

4.2 Most important symptoms and effects, both acute and delayed
See Section 11 (Toxicological Information).

4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically. Contact a poison control center or physician for severe exposure.

5.1 Extinguishing media
Suitable: Water spray, dry chemical, carbon dioxide (CO2), alcohol-resistant foam.
Unsuitable: None known.

5.2 Specific hazards arising from the substance or mixture
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)
Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.
Powder, water spray, foam, carbon dioxide.
Melanine itself does not burn. Use any extinguishing agent suitable for surrounding fire. Poisonous gases including carbon monoxide, hydrogen cyanide, nitrogen oxides, and ammonia are produced in fire. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure position. If employees are expected to fight fires, they must be trained and equipped in OSHA 1910.156.

5.3 Advice for firefighters
Wear self-contained breathing apparatus (SCBA) and full protective clothing.
Fight fire from upwind. Cool containers with water spray until fire is extinguished.

6.1 Personal precautions, protective equipment and emergency procedures
Wear appropriate personal protective equipment (see Section 8).
Avoid breathing dust/vapor. Ensure adequate ventilation.
Evacuate personnel to safe areas. Keep people away from and upwind of spill.

6.2 Environmental precautions
Prevent product from entering drains, waterways, or soil.
Contain spill with inert absorbent material.

6.3 Methods and materials for containment and cleaning up
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Evacuate persons not wearing protective equipment from area of spill or leak until clean-up is complete. Remove all ignition sources. Use HEPA vacuum or wet method to reduce dist during clean-up. Do not dry sweep. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Ventilate area after clean-up is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean-up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable.
Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place (extra personal protection: P2 filter respirator for harmful particles).
DISSOLVED CYANURIC ACID, CYANURATES, & OTHER DERIVATIVES (0.2-3.0%) CONTAINED IN WASTE WATER FROM THE MFR OF CHLORINATED CYANURIC ACIDS ARE REMOVED BY SLURRYING WITH POWDERED OR GRANULATED ACTIVE CARBON FOR 0.5-3 HR & FILTRATION.
ACID WASTEWATERS FROM MFR OF CYANURIC ACID & ITS CHLORINATED DERIVATIVES WHICH CONTAIN CYANURIC ACID, MELAMINE, AMMELINE, & AMMELIDE & HAVE PH 0-6, ARE HEATED TO 245-270 °C UNDER EVOLVED PRESSURE, WHICH MAY BE 1-30 ATM & ARE HYDROLYZED COMPLETELY.
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

7.1 Precautions for safe handling
SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should store this chemical under ambient temperatures, and keep it away from oxidizing materials. (NTP, 1992)
Store in tightly closed containers in a cool, well vented area away form strong oxidizers and strong acids. Where possible, automatically pump liquid from drums or other storage containers to process containers. A regulated, marked area should be established where this chemical is handled, used, or stored in compliance with OSHA standard 1910.1045.

7.2 Conditions for safe storage, including any incompatibilities
Store in tightly closed containers in a cool, well vented area away form strong oxidizers and strong acids. Where possible, automatically pump liquid from drums or other storage containers to process containers. A regulated, marked area should be established where this chemical is handled, used, or stored in compliance with OSHA standard 1910.1045.
Store away from incompatible materials (see Section 10).
[Note: Specific storage temperature not available in public databases. Refer to supplier Certificate of Analysis (COA) for exact storage conditions.]

9.1 Information on basic physical and chemical properties
a) Appearance: Melamine appears as colorless to white monoclinic crystals or prisms or white powder. Sublimes when gently heated. (NTP, 1992)
b) Odor: No data available
c) Odor threshold: No data available
d) pH: No data available
e) Melting point/freezing point: 653 °F (decomposes) (NTP, 1992)
f) Initial boiling point and boiling range: Sublimes (NTP, 1992)
g) Flash point: No data available
h) Evaporation rate: No data available
i) Flammability (solid, gas): No data available
j) Upper/lower flammability or explosive limits: No data available
k) Vapor pressure: 50 mmHg at 599 °F (NTP, 1992)
l) Vapor density: No data available
m) Relative density: 1.573 at 61 °F (NTP, 1992) - Denser than water; will sink
n) Water solubility: less than 1 mg/mL at 72 °F (NTP, 1992)
o) Partition coefficient: n-octanol/water: Log P: No data available
p) Auto-ignition temperature: greater than 500 °F (NTP, 1992)
q) Decomposition temperature: No data available
r) Viscosity: No data available
s) Explosive properties: No data available
t) Oxidizing properties: No data available

9.2 Other information

11.1 Information on toxicological effects
Acute toxicity:
No acute toxicity data available.
Skin corrosion/irritation:
Causes skin irritation (H315).
Serious eye damage/eye irritation:
No data available.
Respiratory or skin sensitization:
May cause an allergic skin reaction (H317).
Germ cell mutagenicity:
No data available.
Carcinogenicity:
Suspected of causing cancer (H351).
Reproductive toxicity:
Suspected of damaging fertility or the unborn child (H361).
Specific target organ toxicity (single exposure):
H373
Specific target organ toxicity (repeated exposure):
No data available.
Aspiration hazard:
No data available.

11.2 Additional information
Carcinogen classification:
Melamine
Group 2B: Possibly carcinogenic to humans
Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)
Volume 73: (1999) Some Chemicals that Cause Tumours of the Kidney or Urinary Bladder in Rodents and Some Other Substances
Volume 119: (2019) Some Chemicals That Cause Tumours of the Urinary Tract in Rodents
2019
2017
Melamine
TR-245: Carcinogenesis Bioassay of Melamine (CASRN 108-78-1) in F344/N
Exposure routes:
Oral (L1775) ; inhalation (L1775) ; dermal (L1775)
Data source: Hazardous Substances Data Bank (HSDB) via PubChem.

12.1 Toxicity
/AQUATIC SPECIES/ EXPOSURE OF BIOMPHALARIA GLABRATA FOR 45 DAYS TO SUBLETHAL CONCN (500, 1000 & 2000 MG/L) OF MELAMINE IN WATER CAUSED A CONCN-DEPENDENT DECREASE IN REPRODUCTIVE ABILITY.
/AQUATIC SPECIES/ MELAMINE AT 500 & 1000 MG/L LOWERED THE RATE OF SALMO GAIRDNERI EGG HATCHABILITY & AT 125 & 250 MG/L IT INCREASED THE INCIDENCE OF MALFORMATION IN EXPOSED LARVAE.
Melamine's production and use in the manufacture of melamine resins, organic synthesis, and leather tanning may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 3.59X10-10 mm Hg at 20 °C indicates melamine will exist solely in the particulate phase in the atmosphere. Particulate-phase melamine will be removed from the atmosphere by wet or dry deposition. If released to soil, melamine is expected to have very high mobility based upon an estimated Koc of 5. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 1.8X10-14 atm-cu m/mole. No biodegradation using a standard 5-day BOD test wasobserved, suggesting that biodegradation may not be an important environmental fate process. If released into water, melamine is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. An estimated BCF of 3 suggests bioconc

12.2 Persistence and degradability
No data available.

12.3 Bioaccumulative potential
No data available.

12.4 Mobility in soil
No data available.

12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available.

12.6 Other adverse effects
No other adverse ecological effects identified.

13.1 Waste treatment methods
Waste Treatment Methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers and do not mix with other waste. Handle uncleaned containers in the same manner as the product itself.

14.1 UN number
Not regulated as dangerous goods (research quantities typically exempt).

14.2 UN proper shipping name
Not subject to transport regulations (small quantities for research use).

14.3 Transport hazard class(es)
Not classified as dangerous goods for transport (research quantities).

14.4 Packing group
Not applicable (not regulated as dangerous goods in typical research quantities).

14.5 Environmental hazards
Marine pollutant: No (not classified as environmentally hazardous per GHS).

14.6 Special precautions for user
Transport in original packaging. Ensure containers are tightly sealed.
For bulk or commercial quantities, consult applicable transport regulations (DOT, IATA, IMDG).

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
US EPA / TSCA: Subject to EPA TSCA regulations
EU ECHA / REACH: Registered under REACH

SARA 302 Components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards:
Acute (short-term) health hazard
Chronic (long-term) health hazard
Fire hazard

Massachusetts Right To Know Components:
This material contains components subject to the Massachusetts Right to Know Act. See Section 2 for hazard classification.
Pennsylvania Right To Know Components:
This material contains components subject to the Pennsylvania Right to Know Act. See Section 2 for hazard classification.
New Jersey Right To Know Components:
This material contains components subject to the New Jersey Right to Know Act. See Section 2 for hazard classification.

California Prop. 65 Components:
This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.

Other regulatory listings:
- The Australian Inventory of Industrial Chemicals: Chemical: 1,3,5-Triazine-2,4,6-triamine
- California Safe Cosmetics Program (CSCP) Reportable Ingredient: Hazard Traits - Carcinogenicity Authoritative List - IARC Carcinogens - 2B Report - regardless of intended function of ingredient in the product
- EFSA Legal Basis: Regulation (EC) No 178/2002 (amended)
- FDA Requirements: Melamine is an indirect food additive for use only as a component of adhesives.

15.2 Chemical safety assessment
A chemical safety assessment has not been carried out for this substance.
For research-use-only compounds, no CSA is required under REACH Annex I.

Revision Date: 2026/09/10
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.