CAS No. 520-85-4

Batch: Purity:99.48
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Medroxyprogesterone Chemical Structure
Chemical Structure
Check the Medroxyprogesterone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 520-85-4
Molecular Formula

C22H32O3
Molecular Weight (MW) 344.49
SMILES CC1CC2C(CCC3(C2CCC3(C(=O)C)O)C)C4(C1=CC(=O)CC4)C

Ordering Information

Biological Activity

Medroxyprogesterone is a synthetic pregnane steroid and a potent progesterone receptor agonist. Upon binding to the progesterone receptor, it promotes receptor dimerization and nuclear translocation, modulating downstream gene expression. This activation regulates classical progesterone signaling pathways to modulate cell proliferation, tissue differentiation, and reproductive function. Additionally, medroxyprogesterone influences cross-talk with cytosolic signaling cascades, including MAPK and AKT signaling pathways, to elicit broad cellular responses. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 68 mg/mL (197.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 14 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.